We retrospectively evaluated a complete of 350 sufferers who underwent a 256-row non-enhanced computed tomography scan on the emergency division for mind trauma. Photos had been reconstructed each with hybrid and model-based iterative algorithm. Two radiologists, blinded to medical knowledge, recorded the presence, nature, quantity, and placement of acute findings. Subjective picture high quality was carried out utilizing a 4-point scale. Goal picture high quality was decided by computing the signal-to-noise ratio and contrast-to-noise ratio.
The settlement between the 2 readers was evaluated utilizing k-statistics. In grownup pre-clinical fashions, traumatic mind damage (TBI) has been proven to prime microglia, exaggerating the central inflammatory response to an acute immune problem, worsening depressive-like habits, and enhancing cognitive deficits. Whether or not this phenomenon exists following mTBI throughout adolescence has but to be explored, with age at damage probably altering the inflammatory response. Moreover, up to now, research have predominantly examined hippocampal-dependent studying domains, though pre-frontal cortex-driven features, together with consideration, motivation, and impulsivity, are considerably affected by each adolescent TBI and acute inflammatory stimuli.
As such, the present research examined the results of a single acute peripheral dose of LPS (0.33 mg/kg) given in maturity following mTBI in mid-adolescence in male Sprague-Dawley rats on efficiency within the 5-choice serial response time process (5-CSRTT). Solely beforehand injured animals given LPS confirmed a rise in omissions and reward assortment latency on the 5-CSRTT, with no impact famous in sham animals given LPS. That is suggestive of impaired motivation and a chronic central inflammatory response to LPS administration in these animals.
Certainly, morphological evaluation of myeloid cells inside the pre-frontal cortex, through IBA1 immunohistochemistry, discovered that injured animals administered LPS had a rise in complexity in IBA1+ve cells, an impact that was seen to a lesser extent in sham animals. These findings counsel that there could also be ongoing alterations within the results of acute inflammatory stimuli which are pushed, partly by elevated reactivity of microglial cells.
Progress in mimicking mind microenvironments to grasp and deal with neurological issues
Neurological issues together with traumatic mind damage, stroke, main and metastatic mind tumors, and neurodegenerative illnesses have an effect on tens of millions of individuals worldwide. Illness development is accompanied by adjustments within the mind microenvironment, however how these shifts in biochemical, biophysical, and mobile properties contribute to restore outcomes or continued degeneration is basically unknown.
Tissue engineering approaches can be utilized to develop in vitro fashions to grasp how the mind microenvironment contributes to pathophysiological processes linked to neurological issues and might also supply constructs that promote therapeutic and regeneration in vivo. On this Perspective, we summarize options of the mind microenvironment in regular and pathophysiological states and spotlight methods to imitate this setting to mannequin illness, examine neural stem cell biology, and promote regenerative therapeutic.
We talk about present limitations and ensuing alternatives to develop tissue engineering instruments that extra faithfully recapitulate the facets of the mind microenvironment for each in vitro and in vivo purposes. 4 well-being profiles had been recognized: low well-being, reasonable well-being, good well-being, and excessive well-being. Elements related to a larger probability of following a greater well-being profile included receiving Housing First, reporting feminine gender and non-white ethnicity, having post-secondary research, and reporting a excessive resilience stage.
Concurrently, elements related to a decrease probability of higher well-being profiles had been having a historical past of continual homelessness, experiences of discrimination within the healthcare setting, having comorbid psychological issues and a excessive stage of symptom severity, and reporting a historical past of traumatic mind damage and childhood adversity. Thirty-six % of sufferers within the LSH program died earlier than finishing comply with up analysis with respect to 18% of demise within the group of TBI sufferers telemonitored at house.
Telemonitoring of Sufferers With Continual Traumatic Mind Damage: A Pilot Examine
Telehealth techniques have proven success within the distant administration of a number of neurological issues, however there’s a paucity of proof in issues of consciousness (DOC). On this research, we discover the effectiveness of a brand new telemonitoring system, for monitoring Vegetative State (VS) and Minimally Acutely aware State (MCS) sufferers. This was a potential, mono-center randomized managed research. We included solely traumatic mind damage (TBI) sufferers who required long-term motor/cognitive help having a steady medical situation.
We examined their medical evolution over ~Four years of the follow-up interval. Twenty-two TBI sufferers had been enrolled and equally divided into two teams: one telemonitored at house with our service and the second admitted to a normal long-stay hospitalization (LSH) program. Sufferers enrolled within the telehealth service (age: 49.9 ± 20.4; 45% feminine; analysis: 36% VS/64% MCS) had been demographically and clinically-matched with these admitted to the LSH program (age: 55.1 ± 15; 18% feminine; analysis: 54% VS/46% MCS).
 Paraffin Tissue Section - Human Adult Normal: Brain: Cerebral Meninges |
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T2234043 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Brain Tumor: Craniopharyngioma |
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T2235035-4 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Ependymal Glioma |
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T2235035-5 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Pilocytic Astrocytoma |
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T2235035-13 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade I |
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T2235035-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade II |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Astrocytoma Grade III |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Malignant Oligodendroglioma |
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T2235035-8 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Pituitary Adenoma with Oncocytic Cell Type |
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T2235035-14 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Bone Tumor |
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T2235023 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Lung Tumor |
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T2235152 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Skin Tumor |
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T2235218 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Colon Tumor |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Liver Tumor |
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T2235149 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Breast Tumor |
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T2235086 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Kidney Tumor |
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T2235142 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Testis Tumor |
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T2235260 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Tonsil Tumor |
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T2235268 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Brain Tumor: Oligodendroglioma and Astrocytoma, Mixed Glioma |
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T2235035-12 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adipose Tumor |
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T2235003 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adrenal Tumor |
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T2235004 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Bladder Tumor |
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T2235010 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain |
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T2234035 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Appendix Tumor |
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T2235006 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Pancreas Tumor |
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T2235188 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Prostate Tumor |
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T2235201 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Abdominal Tumor |
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T2235001 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Parathyroid Tumor |
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T2235189 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Gallbladder Tumor |
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T2235118 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Kidney Tumor: Wilms' Tumor |
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T2235142-7 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Pons |
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T2234071 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Uterus Cervix Tumor |
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T2235275 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adipose Tumor: Lipoma |
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T2235003-1 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Angioma: Glomus Tumor |
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T2235011-2 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Bone Tumor: Chondroma |
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T2235023-2 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Insula |
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T2234055 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adrenal Tumor: Adenoma |
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T2235004-1 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Testis Tumor: Seminoma |
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T2235260-3 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Amygdala |
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T2234036 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Midbrain |
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T2234059 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Thalamus |
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T2234079 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Skin Tumor: Fibrosarcoma |
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T2235218-2 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Parkinson's Disease: Brain |
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T2236035Par |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Pituitary |
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T2234068 |
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5 slides |
EUR 758 |
 Paraffin Tissue Section - Human Pancreas Tumor: Islet Cell Tumor |
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T2235188-3 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Dementia: Brain: Thalamus |
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T2236079Dem |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum |
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T2234039 |
Biochain |
5 slides |
EUR 185 |
 Paraffin Tissue Section - Alzheimers Disease: Brain |
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T2236035Alz |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adrenal Tumor: Myelolipoma |
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T2235004-3 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Bone Tumor: Chondrosarcoma |
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T2235023-3 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Breast Tumor: Fibroadenoma |
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T2235086-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Lung Tumor: Adenocarcinoma |
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T2235152-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Hippocampus |
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T2234052 |
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5 slides |
EUR 629 |
 Paraffin Tissue Section - Depression: Brain: Thalamus |
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T2236079Dep |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma |
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T2235090-1 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Liver Tumor: Adenocarcinoma |
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T2235149-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Diencephalon |
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T2234049 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Dementia: Brain: Hippocampus |
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T2236052Dem |
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5 slides |
EUR 758 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Optic Nerve |
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T2234064 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Tumor Cell Line: MCF-7 |
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T2255830 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Frontal Lobe |
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T2234051 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Pineal Gland |
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T2234067 |
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5 slides |
EUR 330 |
 Brain tumor (meningioma |
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GL2082 |
TissueArray |
each |
EUR 474 |
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Description: Brain tumor (meningioma, astrocytoma and glioblastoma) tissue array, 104 cases/208 cores |
 Brain tumor(meningioma |
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GL2082a |
TissueArray |
each |
EUR 474 |
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Description: Brain tumor(meningioma, astrocytoma and glioblastoma) and brain tissue array, including pathology grade, 104 cases/208 cores (core size 1.0mm), replacing GL2082 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Parietal Lobe |
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T2234066 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Depression: Brain: Hippocampus |
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T2236052Dep |
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5 slides |
EUR 758 |
 Paraffin Tissue Section - Human Appendix Tumor: Adenocarcinoma |
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T2235006-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Pancreas Tumor: Adenocarcinoma |
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T2235188-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Prostate Tumor: Adenocarcinoma |
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T2235201-1 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Basal Ganglia |
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T2234037 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Temporal Lobe |
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T2234078 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Bone Tumor: Synovial Sarcoma |
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T2235023-8 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Choroid Plexus |
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T2234044 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Occipital Lobe |
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T2234062 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Dementia: Brain: Frontal Lobe |
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T2236051Dem |
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5 slides |
EUR 238 |
) Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum (left) |
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T2234040 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Cerebral Cortex |
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T2234042 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Corpus Callosum |
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T2234045 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Dementia: Brain: Parietal Lobe |
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T2236066Dem |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Parkinson's Disease: Brain: Pons |
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T2236071Par |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Abdominal Tumor: Neuofibromatosis |
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T2235001-7 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Skin Tumor: Malignant Melanoma |
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T2235218-3 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Dementia: Brain: Temporal Lobe |
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T2236078Dem |
Biochain |
5 slides |
EUR 238 |
) Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellum (right) |
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T2234041 |
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5 slides |
EUR 185 |
) Paraffin Tissue Section - Human Adult Normal: Brain: Olfactory ( region) |
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T2234063 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Precentral Gyrus |
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T2234073 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Vermis Cerebelli |
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T2234082 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Bone Tumor: Myeloma, Plasmacytic |
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T2235023-7 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Breast Tumor: Lobular carcinoma |
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T2235086-3 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma, MSH |
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T2235090MSH |
Biochain |
5 slides |
EUR 734 |
 Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma, MSS |
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T2235090MSS |
Biochain |
5 slides |
EUR 524 |
 Paraffin Tissue Section - Depression: Brain: Frontal Lobe |
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T2236051Dep |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Dementia: Brain: Occipital Lobe |
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T2236062Dem |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Alzheimers Disease: Brain: Pons |
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T2236071Alz |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Corpora Mamillare |
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T2234047 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Medulla Oblongata |
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T2234057 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Postcentral Gyrus |
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T2234072 |
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5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Tonsilla Cerebelli |
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T2234080 |
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5 slides |
EUR 330 |
 Paraffin Tissue Section - Depression: Brain: Parietal Lobe |
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T2236066Dep |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section – Human Breast Tumor, BRCA Characterized |
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T2235086BRCA |
Biochain |
5 slides |
EUR 524 |
 Paraffin Tissue Section - Human Rectum Tumor: Adenocarcinoma, MSS |
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T2235206MSS |
Biochain |
5 slides |
EUR 524 |
 Paraffin Tissue Section - Human Uterus Tumor: Adenocarcinoma, MSS |
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T2235274MSS |
Biochain |
5 slides |
EUR 524 |
 Paraffin Tissue Section - Depression: Brain: Temporal Lobe |
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T2236078Dep |
Biochain |
5 slides |
EUR 238 |
) Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Ulcer) |
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T2235090-3 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Stomach Tumor: Adenocarcinoma, MSS |
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T2235248MSS |
Biochain |
5 slides |
EUR 524 |
 Paraffin Tissue Section - Human Parotid Tumor: Pleomorphic Adenoma |
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T2235190-5 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Depression: Brain: Occipital Lobe |
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T2236062Dep |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Cerebellar Peduncles |
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T2234038 |
Biochain |
5 slides |
EUR 185 |
 Paraffin Tissue Section - Human Adult Normal: Brain: Tuberculum Cinereum |
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T2234081 |
Biochain |
5 slides |
EUR 330 |
 Paraffin Tissue Section - Human Breast Tumor: Mucous Adenocarcinoma |
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T2235086-6 |
Biochain |
5 slides |
EUR 238 |
) Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Mucoid) |
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T2235090-2 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Parkinson's Disease: Brain: Amygdala |
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T2236036Par |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Parkinson's Disease: Brain: Thalamus |
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T2236079Par |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Lung Tumor: Large Cell Carcinoma |
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T2235152-6 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Lung Tumor: Small Cell Carcinoma |
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T2235152-9 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Tonsil Tumor: Lymphoma of Tonsil |
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T2235268-1 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Bone Tumor: Giant Cell Tumor, Grade I-II |
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T2235023-6 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Multiple Sclerosis Disease: Brain |
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T2236035Msc |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive |
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T2235275HPV+ |
Biochain |
5 slides |
EUR 646.8 |
|
Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
 Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV negative |
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T2235275HPV- |
Biochain |
5 slides |
EUR 646.8 |
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Description: Our tissue products are produced by strictly following the IRB ethical standards and procedures and from highest quality tissues. Immediately after collection the tissues are placed in liquid nitrogen and examined by certified pathologists. The thickness of each individual section is ~5um. They are Hematoxylin and Eosin stained and quality tested by immunostaining with anti-beta-actin antibodies. Our tissue products are suitable for various studies on cellular level (RNA localization, Protein expression, etc.) on both normal and pathological cases. It is also an excellent control and educational tool. |
Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV negative |
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T2235275HPV-negative |
Biochain |
5 slides |
EUR 524 |
Paraffin Tissue Section - Human Uterus Cervix Tumor, HPV positive |
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T2235275HPV-positive |
Biochain |
5 slides |
EUR 524 |
 Paraffin Tissue Section - Human Adult Normal: Blood Vessel: Brain Artery |
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T2234014 |
Biochain |
5 slides |
EUR 185 |
 Paraffin Tissue Section - Alzheimers Disease: Brain: Amygdala |
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T2236036Alz |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Alzheimers Disease: Brain: Thalamus |
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T2236079Alz |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Liver Tumor: Hepatocellular Carcinoma |
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T2235149-4 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Pelvic Tumor: Malignant Mesothelioma |
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T2235193-2 |
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5 slides |
EUR 238 |
 Paraffin Tissue Section - Parkinson's Disease: Brain: Cerebellum |
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T2236039Par |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Kidney Tumor: Clear cell carcinoma |
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T2235142-2 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Human Kidney Tumor: Renal Cell Carcinoma |
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T2235142-5 |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Alzheimer's Disease: Brain: Cerebellum |
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T2236039Alz |
Biochain |
5 slides |
EUR 238 |
 Paraffin Tissue Section - Parkinson's Disease: Brain: Hippocampus |
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T2236052Par |
Biochain |
5 slides |
EUR 758 |
At follow-up, sufferers in LSH and telemonitoring teams confirmed comparable medical development, as measured by CRS-r, NCS, WHIM, and LCF scales, in addition to by the variety of medical issues (i.e., bedsores, infections). Lastly, we estimated the overall every day price per affected person. Extreme TBI sufferers enrolled within the standard LSH program price 262€ each single day, whereas the fee per affected person within the telehealth service resulted to be cheaper (93€). Right here, we spotlight that our telehealth monitoring service is as efficacious as in-person common care to handle a extreme neurological dysfunction similar to TBI in a cheap manner.