Confirmed speakers – Frontiers in TBI 2020
From TBI biomechanics to pathology – quantitative assessment of blood biomarkers and histology changes in a rat model
Cornelius Donat – Imperial College London
Cornelius is a research associate in the Faculty of Medicine, Department of Brain Sciences at Imperial College London. He studied biology in Germany, PhD in Germany as well, investigating cholinergic targets after TBI in a procine and a rodent model using radioactive tracers. Worked at University of Copenhagen in PET tracer design and evaluation and came to London. His main work at Imperial College is understanding the pathology of TBI using animal models and whether computational models can predict the pathology.
The main research interests are disorders of the brain, primarily Traumatic Brain Injury (TBI), the connection with dementia and the underlying molecular processes. A particular interest in nicotinic acetylcholine receptors and how they are involved in cognitive dysfunction and inflammatory processes during TBI and neurodegenerative diseases. Cornelius worked on the visualisation of these receptors with radioactive imaging techniques and will evaluate receptor-specific therapies in TBI and neurodegenerative diseases.
One of the research aims is to increase the understanding of the pathophysiological processes following TBI and how neuro- and molecular imaging can be used to identify major disease processes in order to support the development of new treatment strategies and for that purpose, he employs models of TBI that reduce the complexity of the injury and allow the selective pharmacological manipulation.
Inflammatory profile of a rat model of TBI
Magdalena Sastre – Imperial College London
Magdalena is a Reader in Molecular Neuroscience in the Faculty of Medicine, Department of Brain Sciences at Imperial College London. She graduated in Sciences and did her PhD in Biology and Health Sciences at the University of the Balearic Islands, Spain. She trained in Neuroscience in the USA (Cornell University and New York University) and in Germany (Universities of Munich, Bonn and Frankfurt).
She is interested in the molecular mechanisms whereby inflammation impacts on aging-related neuronal degeneration. During the last 20 years she has been investigating the effect of amyloid-ß (Aß) peptide in neuronal damage by exerting a neurotoxic and neuroinflammatory action and reducing neuronal survival. Her research is based on a multidisciplinary approach using molecular/cell biology, pharmacological, imaging and biochemical techniques to understand the regulation of amyloid precursor protein (APP) metabolism in relation to neuronal degeneration and eventual regeneration.
The projects that are currently carried out in her laboratory are related to the role of the activation of glial cells and neuroinflammation in neurodegeneration, particularly analysing the effects in the development of dementia. For that purpose, her team uses animal models of Alzheimer’s disease (AD) and they have also set up two animal models of traumatic brain injury (TBI), which it is known to accelerate the risk and onset of AD.
Her scientific contributions include the study of the intracellular signalling cascade of the amyloid precursor protein and how it affects its cleavage and the formation of amyloid-β peptide. In addition, she is exploring further treatments for dementia based on their anti-inflammatory and neuroprotective properties, particularly the peroxisome proliferator-activated receptor-γ (PPAR-γ) activators. During the past few years she has been studying the role of the PPARγ cofactors, in particular the coactivator PGC1α, showing that increased expression of the co-factor PGC1α using gene therapy leads to reduced AD pathology, improved memory and decreased neuronal loss (Katsouri et al, 2016).
Development of experimental models to understand different components of a complex TBI
Mårten Risling – Karolinska Institutet
Mårten is the leader of the experimental traumatology research unit at Department of Neuroscience, Karolinska institutet in Stockholm, Sweden. He has a MD (1984) and PhD (1983) from Karolinska institutet. 1986 he became associate professor at Karolinska institutet. Dr Rislings early studies revealed a capacity for motoneurons to bridge lesions in ventral funiculus of the spinal cord or at the CNS/PNS border. This was the starting point for studies on replantation of avulsed ventral roots with Thomas Carlstedt and Staffan Cullheim. In 2000 he joined the Swedish Defence Research Agency as leader of the defence related neurotrauma research activities. The unit was transferred to Karolinska institutet in 2008.
Dr. Risling is now professor of anatomy at the Karolinska and Speciality Chief Editor for the Neurotrauma section of Frontiers in Neurology. The focus of the research activities is to study effects of different types of Traumatic Brain Injury (TBI). In close collaboration with Dr. Johan Davidsson at Chalmers in Gothenburg the group has developed unique models for penetrating TBI and rotational acceleration injury. These models can be used to define thresholds for lesions such as diffuse axonal injury (DAI).
Clinical utility of protein biomarkers in the management of traumatic brain injury
Eric Thelin – Karolinska Institutet
Erich graduated from Karolinska Institutet 2009 after electives in Neurosurgical Care and Critical Care at Mount Sinai School of Medicine, New York City, NY, USA. Been working at the Neurosurgical Department at Karolinska University Hospital 2009 – 2015 with a pause for Clinical Rotations (Internship/AT-läkare) at Capio S:t Görans Hospital 2010-2012. Defended his thesis entitled “On Biomarkers In Traumatic Brain Injury” in May 2015 and have been working as a postdoctoral researcher at the Department of Clinical Neuroscience, Karolinska Institutet to July 2016. Between 2016-2018, Eric was a post-doctoral researcher at the Department of Clinical Neurosciences at the University of Cambridge with neuroinflammation and neuro-monitoring as primary research areas. Today, Eric is a ST doctor in Neurology at the Karolinska University Hospital but continuing his research at Karolinska Institutet in primarily the areas of protein biomarkers, traumatic brain injury management, neuro-intensive care, neuroinflammation, multimodal monitoring and microdialysis.
Epigenetics and proteomics in severe human TBI
Niklas Marklund – Lund University.
Chair of the Section of Neurotrauma & Critical Care
Niklas is a professor and academic chair at the Department of Neurosurgery at Lund University, Sweden, as well as professor of neurosurgery at Uppsala University, Sweden. He went to medical school in Umeå, Sweden and had his neurosurgical training in Uppsala. After his PhD on traumatic brain injury in 2001, he spent two years as a post-doctoral fellow in Philadelphia, USA continuing his research on neurotraumatology. His main clinical and scientific areas of interest are neurotraumatology that includes experimental as well as clinical research and ranges from sports-related concussions to neurocritical care topics, vascular disorders and spinal neurosurgery.
Niklas Marklund was 2010-2016 the Swedish representative in the EANS training committee as well as the scientific secretary of the Swedish Neurosurgical Society. He hosted the 2015 Uppsala training course, is a current member of the EANS exam committee and is a Swedish course leader for the annual Scandinavian neurosurgical courses, Beitostolen, Norway. He is the current mentor of 5 PhD students and on the editorial board or associate editor of five journals including Frontiers in Neurology- Neurotrauma, Journal of Neurotrauma and Acta Neurochirurgica. He is elected member of the Scandinavian Neurotrauma Committee, European Brain Injury Consortium, and the Neurotrauma Committee of the WFNS. Niklas Marklund has a genuine sports interest and enjoys the art of piano playing. He is of course an individual member of the EANS and was in October 2017 elected as the section chair of Trauma & Critical Care of the EANS.
Update on fluid biomarkers for TBI – Research and potential clinical utility
Henrik Zetterberg – University College London/University of Gothenburg
Henrik is a Professor of Neurochemistry at the University of Gothenburg, Sweden, and University College London, UK, and a Clinical Chemist at Sahlgrenska University Hospital in Gothenburg. He is Head of the Department of Psychiatry and Neurochemistry at the University of Gothenburg and leads the UK DRI Fluid Biomarker Laboratory at UCL. His main research focus and clinical interest are fluid biomarkers for central nervous system diseases. He has published more than 1200 papers and has received numerous awards.
A critical overview of evidence for training-dependent structural neuroplasticity in brain-injured patients
Karen Caeyenberghs – Deakin University
Professor Karen Caeyenberghs is a psychologist and neuroscientist. Her research interests are focused on mechanisms underlying neuroplasticity in brain-injured patients using a multidisciplinary approach, spanning the behavioural sciences and the cognitive neurosciences with a specific focus on the study of brain structure and connectivity using medical imaging technologies. Her contributions include publishing the first studies using diffusion MRI in children with TBI; developing novel home-based training programs for brain injured populations (BrainGames and CogMo); providing the first evidence of chronic cognitive impairments from a disconnection syndrome perspective; and publishing some of the first brain-wide maps of dynamic structural connectivity changes with training and disease progression. She holds an NHMRC Career Development Fellowship, with a focus on the underlying mechanisms of secondary injury of traumatic brain injury.
Professor Caeyenberghs is the Program Leader for Neuroplasticity and Multimodal Imaging (NMI) at the Cognitive Neuroscience Unit and she co-leads the paediatric moderate-severe TBI consortium (enigma.ini.usc.edu/ongoing/enigma-tbi/) examining the impact of brain injury on the developing brain. She has previously worked at the Australian Catholic University, University of Ghent, Cardiff University Brain Research Imaging Center, and Catholic University of Leuven. Professor Caeyenberghs has authored over 100 scientific articles in high-impact international peer-reviewed journals (e.g., Brain, Neuroimage, Developmental Science, Neurorehabilitation and Neural Repair, Journal of Neuroscience) and she has acted as a reviewer for over 20 academic journals. She has received over $2.5million in research funding. Bodies that have funded her research include the National Health and Medical Research Council (NHMRC) and the Flanders Fund for Scientific Research (FWO).
The treatment of sleep disturbances and fatigue after TBI
Jennie Ponsford – Monash University
Jennie Ponsford, AO, BA (Hons), MA (Clin Neuropsych), PhD, MAPsS, is a Professor of Neuropsychology and Director of Clinical Programs in the School of Psychological Sciences at Monash University and Director of the Monash-Epworth Rehabilitation Research Centre at Epworth Hospital in Melbourne. She has spent 40 years engaged in clinical work and research with individuals with brain injury, investigating outcomes following mild, moderate and severe traumatic brain injury, factors predicting outcome and the efficacy of rehabilitative interventions. She has published over 350 journal articles and book chapters and two books on these subjects. She is Past-President of the International Neuropsychological Society, the International Association for the Study of Traumatic Brain Injury and the Australasian Society for the Study of Brain Impairment, and serves on the Executive of the International Brain Injury Association and Australasian Society for the Study of Brain Impairment ASSBI, of which she is an Honorary Fellow. In 2013 she was awarded the Robert L. Moody prize for Distinguished Initiatives in Brain Injury and Rehabilitation and in 2015 the International Neuropsychological Society’s Paul Satz Career Mentoring Award. In 2017 she was made an Officer of the Order of Australia for her distinguished contributions to neuropsychology and seminal advances in the diagnosis, treatment and rehabilitation of patients with traumatic brain injury.
Remotely deliverable computerised cognitive assessment for TBI patients: sub-scale validation and structural-imaging correlates
Adam Hampshire – Imperial College London
Dr Hampshire is a Reader at Imperial College London. He leads a group within the Computational, Cognitive and Clinical Neuroimaging Laboratory and is a UKDRI Associate Member. His work involves a novel fusion of experimental psychology, psychometrics, imaging, brain stimulation and computational methods. Dr Hampshire has a track record of developing technology for basic research and translating it for clinical application.
His software for large scale remote cognitive assessment via Apps and the Internet has been used to assess hundreds of thousands of people, produced publications in journals including Nature and Neuron, received international media coverage, and produced a successful spin out company. It formed the basis of The Great British Intelligence Test, which in collaboration with the BBC, tested a quarter of a million members of the general publics during January 2020.
His fMRI paradigms, designed to differentially probe cognitive brain systems, have led to publications in lead journals including Neuron, Cerebral Cortex and Nature Communications, and enabled research in diverse clinical populations, e.g., obsessive compulsive disorder (Science & Biological Psychiatry) and Parkinson’s disease (Brain). This technology is being applied extensively in research with ageing populations and neurotrauma patients, with support from the NIHR.
The social brain: Implications of Traumatic Brain Injury
Niall Bourke – Imperial College London
Niall completed his undergraduate Psychology degree in Dublin, developing a strong interest in traumatic brain injury (TBI). After working as rehabilitation assistant at Acquired Brain Injury Ireland, he moved to London to complete an MSc in Neuroimaging at King’s College London, where he was involved in various projects, including the effects of emotional stimuli on functional activation under influence of tetrahydrocannabinol (THC), as well as a large-scale study on neurodevelopmental trajectories in Romanian adoptees.
Following this, he joined the Computational, Cognitive, and Clinical Neuroimaging Laboratory at Imperial College London as a research assistant, where he worked on disruption to the dopaminergic system following TBI before beginning his PhD investigating deficits in social and emotional processing, as well as impaired insight and metacognition following TBI. He has since transitioned into an imaging analysis position at Imperial, collaborating with a multidisciplinary team at Great Ormond Children’s Hospital (GOSH) to explore arrested development following paediatric TBI.
Niall is an avid climber and has a keen interest in space. When not in the office, he can often be found either on a boat or on anything he can get his hands on that will take him out to sea.
Network dysfunction in paediatric TBI: Update on the first UK-based study
Célia Demarchi – Imperial College London
Dr Célia Demarchi is a Clinical Psychologist in Paediatric Neuropsychology. Since qualifying with a Doctorate from the University of Oxford in 2016, she has been working on a new research collaboration investigating network dysfunction following paediatric traumatic brain injury (TBI). Her research, based in Imperial College London and Great Ormond Street Hospital, uses neuropsychology and advanced neuroimaging to study brain network function and how this relates to behaviour following TBI in children and adolescents. She has been instrumental in creating the UKs first clinical academic network of professionals working with young people who have had a TBI bringing together professionals from over 10 acute hospitals, rehabilitation centres and the charitable sector.
Célia holds an honorary contract at Great Ormond Street Hospital and has a particular therapeutic interest in how children and families adjust to chronic illness.
The R words: repair, restitution, recovery, rehabilitation
Rob Forsyth – Newcastle University
Rob Forsyth is a Senior Lecturer at Newcastle University and Honorary Consultant in Paediatric Neurology for Newcastle Hospitals NHS Foundation Trust. After qualifying from Cambridge and Oxford he trained in Nottingham and Newcastle with subspecialty training in Vancouver. His research interests centre on translational research in paediatric acquired brain injury and rehabilitation and epilepsy. He is an active acute paediatric neurologist: clinical responsibilities include co-ordination of the inpatient acquired brain injury service. He was UK national training advisor in paediatric neurology 2003-9. He is editor of the Oxford Specialist Handbook in Paediatric Neurology (third edition 2017). He was on the editorial boards of Developmental Medicine and Child Neurology 2005-11 and European Journal of Paediatric Neurology 2013-date. He is currently Secretary of the European Paediatric Neurology Society.
Michel Thiebaut de Schotten – Bordeaux University
With over ten years’ experience in neuropsychology and brain connectivity neuroimaging, Michel has already established himself as a leader in the field with a solid scientific track record. Michel has contributed a number of innovative methods and fundamental new discoveries that have important implications for theories of brain structure and function. Hence his work spans the whole gamut from the development of novel methodology to experimental work to theory. Critically, he is dedicating significant effort toward the clinical translation of his neuroscience work through an open model approach that makes my tools freely accessible to the community. For instance, his work published in Science (2005), revealed that spatial neglect is a consequence of the disruption of communication between the frontal and the parietal lobes, and thus should be considered as a disconnection syndrome. He mapped, for the first time, the organisation of white matter anatomy in the healthy human living brain and was published in Nature Neuroscience (2011), Neuroimage (2011), Cortex (2012) as well as in the Atlas of the Human Brain Connections (Oxford University Press, 2012). He has also pursued work concerning brain connectivity in stroke populations by identifying new brain-behaviour association released recently my open software BCBtoolkit (GigaScience 2018; http://toolkit.bcblab.com).
He is the founder of the BCBlab (http://www.bcblab.com). As a practised neuroscientist, his expert opinion is frequently sought by high-level scientific journals including Nature Communications Biology, Neuroimage, Cortex, Brain Structure and Function and Neuroinformatics where he currently serve as Associate Editor. In 2015, he was awarded the prestigious British Neuropsychological Society’s Early Career Award: The Elizabeth Warrington Prize and the ‘Cortex’ Prize. At present, he is a tenured CNRS Research Director in Bordeaux and leads a team of 10 tenured researchers and engineers.
An update from CENTER-TBI: Insights and Intuitions
David Menon – University of Cambridge
Head, Division of Anaesthesia, University of Cambridge
Honorary Consultant, Neurosciences Critical Care Unit, Addenbrooke’s Hospital
Professorial Fellow, Queens’ College, Cambridge
Emeritus Senior Investigator, National Institute for Health Research, UK
Chair, European Brain Injury Consortium
David Krishna Menon is Professor and Head of the Division of Anaesthesia, and Professorial Fellow in Medicine at Queens’ College, Cambridge. He is Principal Investigator at the Wolfson Brain Imaging Centre and at the John van Geest Centre for Brain Repair in Cambridge, and Co-Chairs the Acute Brain Injury Program at the University of Cambridge. He is Chair of the European Brain Injury Consortium. He currently acts as Vice-Coordinator of the CENTER-TBI project, a €30 million FP7 European multicentre study, traumatic brain injury, and as Joint Director of the Cambridge NIHR Global Health Research Group on Neurotrauma. He has over four hundred publications in peer reviewed journals, and is one of two lead authors on a Commissioned Issue of the Lancet Neurology on Traumatic Brain Injury which was released at the European Parliament on the 7th of November 2017, and, in 2018, was Executive Editor of “Time for Change” – the report of the UK Parliament’s All Party Parliamentary Group on Acquired Brain Injury. He serves as one of the Scientific Leads for the International Initiative for Traumatic Brain Injury Research (InTBIR; https://intbir.nih.gov/)
Psychotropic and pain medication use in individuals with traumatic brain injury—A Swedish total population cohort study of 240,000 persons
Yasmina Molero Plaza – University of Oxford
Yasmina is a researcher at the Department of Clinical Neuroscience at the Karolinska Institute in Sweden, and a visiting researcher at the Department of Psychiatry at the University of Oxford. Dr. Molero conducts pharmacoepidemiological research using national health registers, with a specific focus on the risks and benefits of medication use in individuals who have been treated for TBI.
Remote clinical trials of prescription digital therapeutics for sequelae of Traumatic Brain Injury: Using technology in the time of coronavirus
David Brody – Uniformed Services University
Dr Brody was named Director of the CNRM and joined the USUHS faculty in August of 2017. His primary appointment is as Professor of Neurology in the F. Edward Hebert School of Medicine.
Dr. Brody is a board-certified neurologist with both a research and a clinical specialization in TBI and neurodegenerative diseases. Prior to his directorial and faculty position, Dr. Brody was the Norman J. Stupp Professor of Neurology at the Washington University School of Medicine in St. Louis. Dr. Brody was also the Washington University site director for the National Football League Neurological player care program.
Dr. Brody earned a B.A. in Biological Sciences from Stanford University in 1992 and his M.D. and Ph.D. from The Johns Hopkins School of Medicine in 2000. He completed his internship and neurology residency at Washington University.
Dr. Brody’s achievements have been recognized with several awards, including a Career Development Award from the National Institute of Neurological Disorders and Stroke (NINDS), a Burroughs Wellcome Career Award in the Biomedical Sciences, two large Department of Defense awards and a National Institutes of Health (NIH) R01 award. His clinical monograph entitled Concussion Care Manual: A Practical Guide was published by Oxford University Press in 2014. Dr. Brody is a member of the Editorial Board of the Journal of Neurotrauma and Acta Neuropathologica and a permanent member of the NIH Acute Neural Injury and Epilepsy study section.
Dr. Brody’s research focuses on accelerating implications for better diagnosis, treatment and outcomes of traumatic brain injury in civilian and military populations.
Mechanical characterisation of human and animal brain tissue under dynamic loading conditions
David MacManus – Dublin City University
David graduated with a degree in Mechanical and Manufacturing Engineering from Trinity College Dublin in 2013. Following this, David began his PhD studies at University College Dublin where his research focused on the biomechanics of traumatic brain injury. His PhD thesis was awarded the Broberg Medal for Best PhD Thesis in Mechanics at University College Dublin in 2017. In 2018, David was awarded a Science Foundation Ireland Industry Fellowship to investigate the biological mechanisms underlying insulin-induced injection-site lipohypertrophy. David has since joined the School of Mechanical & Manufacturing Engineering at Dublin City University as an Assistant Professor of Biomedical Engineering. David’s research focuses on the biomechanics of traumatic brain injury, and in particular, on mechanical characterisation of brain tissue.
Predicting traumatic brain injury pathologies using computational biomechanics
Mazdak Ghajari – Imperial College London
Dr Mazdak Ghajari is a Senior Lecturer (Associate Professor) in Biomechanics and Design Engineering at Dyson School of Design Engineering, Imperial College. He leads the TBI biomechanics theme at Imperial College with his team in the HEAD lab (https://www.imperial.ac.uk/human-experience-analysis-design/) and has strong cross-faculty collaboration with colleagues in Department of Brain Sciences. Their joint effort has led to new understanding of the links between the initial loading and post-traumatic pathology, improvements in the design of prevention systems and new proposals for better head protection testing standards.
Can head protection reduce the risk of concussion in sports?
Stefan Duma – Virginia Tech
Stefan is the Harry Wyatt Professor of Engineering and interim director of the Institute for Critical Technology and Applied Science. His internationally recognized research on head and eye injuries has covered everything from concussion prevention in football to eye damage from fireworks.
In 2017 he was appointed as the editor-in-chief of the Annals of Biomedical Engineering, the flagship journal of the Biomedical Engineering Society. Duma has served on the editorial board of ABME since 2009. As an associate editor, he spearheaded a drive to increase the journal’s coverage of injury biomechanics, a strategic initiative that boosted the publication’s citation metrics as well as coverage of its papers in the media.
Duma’s own studies of impact biomechanics have transformed the field’s understanding of head and eye injuries and driven the development of safer equipment and procedures in sports, the automotive and consumer-products industries, and the military. He has authored 483 publications, including 144 journal papers and two books, and won more than $51 million in external funding from sources, including the NIH, NSF, DOD, DOT, FAA, and industry sponsors.
Duma revolutionized the field of concussion biomechanics when he became the first researcher to install wireless acceleration sensors in football helmets in 2003, an innovation that allowed his team to measure hundreds of thousands of real-world head impacts. The data his techniques generated about head impact exposure in college, high school, middle school, and youth football led to national changes in rules and regulations; in youth football alone, those changes have prevented an estimated 150 million head impacts per year.
Duma also developed methods to recreate those impacts in the lab, facilitating controlled, realistic tests of safety equipment. The result was the Virginia Tech Helmet Ratings, which Duma released in 2011 in collaboration with Steve Rowson, an assistant professor of biomedical engineering and mechanics in the College of Engineering. The five-star rating system was the first tool to offer consumers quantitative, evidence-based information about how well a particular helmet reduces concussion risk. It has spurred the design of safer headgear for football, as well as hockey, which was added to the ratings in 2014; the research team is expanding to other sports, including cycling and soccer.
Duma is the lead investigator at Virginia Tech for a $30 million research partnership between the National Collegiate Athletic Association and the Department of Defense, a project that has shed new light on the biomechanics of gender differences in sports-related concussion. He was also the founding director of the university’s Center for Injury Biomechanics, now the world’s largest injury biomechanics group.
Traumatic Brain Injury on Great Britain’s roads: predicting severity and pathology with delta-V
Claire Baker – Imperial College London
Claire graduated from the University of Southampton in 2017 with a first class honours in Physics after spending her Masters year conducting large-scale data analysis at Harvard University’s Smithsonian Center for Astrophysics. She joined Imperial College London’s Centre for Doctoral Training in Neurotechnology in 2017 and completed her MRes with distinction in 2018. Since then, she has been working on her PhD: a joint project between Imperial College London’s Dyson School of Design Engineering (HEAD Lab), Imperial Medicine (C3NL) and industry partner the Transport Research Laboratory (TRL). Claire’s PhD research, the AutoTRIAGE project, lies at the exciting intersection of the automotive, medicine and engineering industries. She is investigating the feasibility of predicting Traumatic Brain Injury in Road Traffic Collisions using in-vehicle sensors. She is supported by Dr Mazdak Ghajari (Dyson School of Design Engineering), Prof. David Sharp and Prof. Mark Wilson (Imperial College London’s Department of Medicine) and Dr Phil Martin (TRL). She has additional project experience working with Event Data Recorders and Advanced Automatic Collision Notification systems through her industry partner, TRL.
TBI from Intimate Partner Violence is the Epidemic for us to Address
Jonathan Lifshitz – University of Arizona
Jonathan directs the Translational Neurotrauma Research Program as Professor of Child Health at the University of Arizona to develop tools, refine procedures, and grow knowledge in the clinical care of acquired neurological injury. His research efforts investigate traumatic brain injury as a disease process that dismantles, repairs and regenerates circuits in the brain, with a focus on inflammatory mechanisms of injury and experiential learning approaches to rehabilitation. In the community, he develops approaches to account for traumatic brain injury in the domestic violence population in terms of incidence, awareness, education, and availability of care. He continues to lead local, state, and federal funded projects. He and his trainees have won a dozen national or international awards for research on traumatic brain injury and the NCAA/DOD Mind Matters Challenge for Concussion Education. He has more than 80 peer-reviewed publications, in addition to other monographs and book chapters. He chairs the Arizona Governor’s Council on Spinal and Head Injury, co-hosts the COM-P podcast ReImagine Medicine, and is the Lead Scientist and Director of Research and Development for The CACTIS Foundation.
Treatment of people with brain injuries in the Criminal Justice System
Tara McCarthy is a criminal barrister based at Thomas More Chambers, Lincoln’s Inn Fields, London. She has been in practice for over 23 years, prosecuting and defending all areas of criminal law including murder and violence, drugs and fraud. She is a sexual offences specialist and has been trained to deal with vulnerable witnesses and defendants.
Neuropsychology and TBI medico legal cases
Daniel is a Clinical Psychologist registered with the Health Care and Professions Council, and a Consultant Clinical Psychologist. He worked in Neurorehabilitation since 1999. Daniel is an Honorary Clinical Research Fellow in the Division of Brain Sciences, Department of Medicine, at Imperial College, London. He provides neuropsychology input in Professor Sharp’s Neurology-led traumatic brain injury service, and he is part of the multi-disciplinary treating team.
Daniel is involved in research in this service and works as a Consultant Clinical Neuropsychologist at PPCS, 14 Devonshire Place, W1G 6HX. He is also an Honorary Lecturer in the Research Department of Clinical, Educational & Health Psychology at University College London.
Daniel has particular experience in setting up NHS community neuropsychology services for people suffering from acquired brain injury, and traumatic brain injuries in particular. He assesses and treats individuals with brain injury. and have written articles on brain injury including classification systems of traumatic brain injury and outcome following traumatic brain injury. He is also involved in medico legal work on a regular basis.
The impact of the link between early onset dementia and TBI on damages
Sally Moore – Leigh Day
Sally is head of the personal injury team at Leigh Day, a claimant only law firm. She has spent almost 30 years acting for clients who have suffered severe brain, spinal, amputation and other live-changing or fatal injuries. She is regarded by market sources as as “an outstanding, impeccable lawyer” who is “very well regarded, very committed and good at what she does.”
Chambers and Partners legal directory 2020 describes Sally as a Star Individual ‘among the country’s standout practitioners for high-value personal injury accident claims’.
She is Chair of Headway West London, a Fellow of the Association of Personal Injury Lawyers and is an APIL Accredited Brain Injury Specialist.
Decisions, Decisions, Decisions: Assessing borderline capacity cases in brain injury litigation
Sarah Griggs – Irwin Mitchell
Sarah joined Irwin Mitchell in 2006 and as a Partner in the Serious Injury team she specialises in complex cases involving life changing injuries.
With a particular interest in brain injury cases, Sarah is accredited as a brain injury specialist by the APIL injury Accreditation Scheme. Sarah has close links with Headway and was appointed as a Trustee of Headway East London in 2013. Sarah is also a Committee member for the Acquired Brain Injury Forum for London (ABIL) and she is keen to raise awareness of acquired brain injury across London and the UK. Sarah is passionate about rehabilitation and has extensive experience of securing early interim payments for her clients to ensure that their rehabilitation can start as soon as possible.
Molecular mechanisms of chronic neuroinflammation following experimental TBI
David Loane – Trinity College Dublin
David Loane is an Assistant Professor in the School of Biochemistry and Immunology, Trinity College Dublin, Ireland, and Adjunct Associate Professor at the Shock, Trauma, and Anesthesiology Research (STAR) Center at the University of Maryland School of Medicine (UMSOM), Baltimore, MD, USA. Dr. Loane conducted his graduate studies in the Department of Pharmacology and MRC Center for Synaptic Plasticity, University of Bristol, England. He then pursued postdoctoral training in CNS injury and neuroinflammation at Trinity College Institute of Neuroscience, Trinity College Dublin, Ireland and the Department of Neuroscience, Georgetown University, Washington DC, USA. He was a Faculty member in the Department of Anesthesiology and STAR Center, UMSOM from 2009-2018, and he has recently returned to Dublin to establish a pre-clinical neurotrauma and neuroimmunology research group in Trinity College Dublin. Dr. Loane leads a multi-disciplinary team of researchers dedicated to studying the complexities of traumatic brain injury, neuroinflammation, and tissue repair.
More than bystanders in neurologic diseases –learning what microglia do
Soyon Hong – University College London
Soyon received her PhD in Neuroscience in 2012 from Harvard University and completed her postdoctoral fellowship at Boston Children’s Hospital/Harvard Medical School in 2018. Dr. Hong started her independent laboratory at the University College London in October 2018 as a UK Dementia Research Institute Fellow. Dr. Hong is dedicated to the studying of how the nervous and immune systems in the brain and the gut work together to maintain proper brain homeostasis, and how this goes awry in disease. Dr. Hong studied microglia biology with Dr. Thomas Möller (2002-2006), in vivo beta-amyloid dynamics with Dr. Dennis Selkoe (2007-2012), and microglia-synapse interactions with Dr. Beth Stevens (2012-2018), where she identified microglia as synaptic saboteurs in Alzheimer’s disease models.
What tests are performed, what do they mean, how do we interpret problematic cases etc
Adel Helmy – University of Cambridge
Adel Helmy is a consultant neurosurgeon and a University Lecturer in Neurosurgery. His academic interest is in neurotrauma with a particular focus on translational medicine and neuroinflammation.
Symptom subtypes of sport-related concussion: Clinical relevance of a data-driven approach
Marsh Königs – VU University Amsterdam
Together with Prof. Dr. Jaap Oosterlaan, dr. Marsh Königs initiates and supervises neuroscientific research in the field of paediatrics. This research is focused on the impact of disease and intervention on the structure and function of the child’s brain. Dr. Königs specializes in the use and development of computerized neurocognitive tests, advanced analysis of neurocognitive test performance, eye-tracking and advanced magnetic resonance imaging of brain connectivity. The ultimate goal of his work is to contribute to clinical practice through (i) a better understanding of impairment mechanisms, (ii) improved outcome prediction (e.g. development of prognostic models using machine learning algorithms), (iii) evaluation of treatment efficacy in existing and novel interventions and (iv) development of outcome measures (e.g. neurocognitive test development).
Advanced Computerized Neurocognitive Testing
Dr. Königs specializes in the use and development of computerized neurocognitive tests and advanced analysis of task performance (e.g. Ex-Gaussian analysis, diffusion model analysis). Work in progress is Emma’s Toolbox, an in-house designed battery of computerized tests to measure neurocognitive functions in children. Emma’s Toolbox involves a fixed core battery that uses parametric difficulty manipulation and built-in contrast conditions to isolate neurocognitive processes in the following domains: information processing, attention, learning and memory, executive functioning, sensory functioning and motor functioning. The core battery can be expanded with modules for further assessment of specific neurocognitive functions of interest, such as emotion recognition, language or visual short-term memory. Emma’s Toolbox is an expanding battery: new modules become available by continuous test development.
Magnetic Resonance Imaging (MRI) of Brain Connectivity
Advanced MRI sequences are used to study the impact of disease and treatment on white matter integrity and brain connectivity. Based on diffusion tensor imaging, tract-based statistics is used to study white matter integrity, while structural connectivity is studied by probabilistic fibre tracking in combination with graph theory. Resting-state functional MRI is used to measure functional brain connectivity, using independent component analysis of resting-state networks as well as graph theory.
Neuroimaging in contact sports: Findings from a study of active elite rugby players
Karl Zimmerman – Imperial College London
Karl has spent his academic career at Imperial College, graduating with degrees in Biochemistry and Neuroscience and now working as a researcher at the Computational, Cognitive and Clinical Neuroimaging Laboratory. He has worked on large scale imaging studies over a wide range of modalities including the current EU-wide BIO-AX TBI study and is simultaneously pursuing his PhD: a joint project with Imperial College London’s Dyson School of Design Engineering (HEAD Lab).
Karl’s PhD research is focused on sports related head injuries and lies at the intersection of biomechanics and neuroimaging. He is investigating the utlity of impact simulations in predicting player outcomes and additionally using advanced neuroimaging techniques to investigate axonal injury after sports related head injuries. He is supported by Prof. David Sharp and Dr Mazdak Ghajari (Dyson School of Design Engineering) and works in collaboration with the Rugby Football Union. Karl also spends free time organising conferences.
Challenges in identifying the EEG signature of sports-related concussion in the adolescent brain
Naznin Virji-Babul – University of British Columbia
Dr. Virji-Babul is a Neuroscientist and a physical therapist. She is currently an Associate Professor in the Dept. of Physical Therapy, UBC. Her laboratory is based at the Djavad Mowafaghian Centre for Brain Health. Her research addresses fundamental aspects of brain-behavior relationships in typical and atypical development. Over the past decade, she has adopted a cognitive neuroscience framework using a variety of neuroimaging tools, from magnetoencephalography (MEG) and high-density electroencephalography (EEG), to diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), to unravel and examine the structural and functional brain networks underlying perception and action. This work has resulted in over 60 peer-reviewed papers in the area of neuroimaging, brain dynamics and perceptual-motor function in typical development, atypical development and in adolescents with concussion/mild traumatic brain injury.
Pituitary hormone problems after TBI
Tony Goldstone – Imperial College London
Tony Goldstone is Head of the PsychoNeuroEndocrinology Research Group, Division of Psychiatry, and Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Brain Sciences, Imperial College London.
He attended medical school at Cambridge and Oxford Universities, and obtained a PhD from Imperial College. He is a Fellow of The Obesity Society.
His clinical experimental medicine research studies the risk factors and consequences of pituitary hormone dysfunction after traumatic brain injury through a specialist multi-disciplinary TBI clinic at St. Mary’s Hospital. He has developed guidelines with the Ministry of Defence for endocrine screening after blast and non-blast TBI. His research uses multi-modal phenotyping, including functional and structural neuroimaging.
He is as a Consultant Endocrinologist at Imperial College Healthcare NHS Trust.
Neuropsychiatric problems following Traumatic Brain Injury
Simon Fleminger – Imperial College Healthcare
Dr Fleminger is a neuropsychiatrist who led the Brain injury clinic at the Maudsley hospital for many years. He now works with Professor Sharp and Dr Goldstone in the brain injury clinic at Imperial Healthcare NHS Trust, and undertakes medicolegal work. His research interests are centred on the neuropsychiatry of acquired brain injury.
Neuropsychological assessment in Traumatic Brain Injury
Narinder Kapur – Imperial College Healthcare
Narinder is a visiting Professor of Neuropsychology at University College London, and honorary consultant neuropsychologist at Imperial College NHS Trust. He was Head of Neuropsychology at the Wessex Neurological Centre, Southampton and also at Addenbrooke’s Hospital, Cambridge. He is past President of the British Neuropsychological Society, and he has authored/edited four books in the field of Neuropsychology, including an award-winning book, The Paradoxical Brain. He received a Lifetime Achievement Award from the British Psychological Society.
Hyperacute management of TBI
Mark Wilson – Imperial College London
Mark is a Clinical Professor specialising in Brain Injury at Imperial and Honorary Professor of Pre-Hospital Care (the Gibson Chair) at the Faculty of Pre-Hospital Care, Royal College of Surgeons, Edinburgh.
He is a Consultant Neurosurgeon and Pre-Hospital Care Specialist working at both Imperial College (mainly St Mary’s Major Trauma Centre) and as an Air Ambulance doctor.
His specialist areas are acute brain injury (mostly traumatic brain injury) and its very early management. I am co-director of the Imperial Neurotrauma Centre.
He is the co-founder of GoodSAM, a revolutionary platform that alerts doctors, nurses, paramedic and those trained in basic life support to emergencies around them. He worked extensively overseas (India, Nepal, South Africa, as a GP in Australia, Researcher for NASA and as an expedition doctor on Arctic and Everest expeditions). He wrote The Medics Guide to Work and Electives Around the World.
His research is mainly into the brain in trauma and in hypoxia (using it as an injury model) in humans.
Getting rid of post-concussion syndrome as a diagnosis
Peter Jenkins – Imperial College London
Peter Jenkins is a Neurology Consultant in south London. He runs a traumatic brain injury clinic that specialises in treating the milder end of the TBI spectrum. He has also recently set up a carbon monoxide exposure clinic focussing on the neurological sequelae of CO exposure. He has carried out research in TBI specifically focussing on patient stratification to aid treatment selection. He is currently running a study into the effects of CO on the brain.
The future of rehabilitation – what does technology have to offer?
Sarah Daniels – Imperial College London
Sarah is an occupational therapist (OT) with experience and expertise in the field of neurorehabilitation. Over the past 25 years, she has worked across a range of healthcare settings both in the UK and in the USA , latterly leading specialist neuro-rehabilitation services within the NHS; National Hospital for Neurology and Neurosurgery and Imperial College Healthcare NHS Trust
Sarah has a long held interest in the use of technology to assess and support functional performance within real world contexts as well as neuromodulation to enhance existing rehabilitation approaches. She recently joined the UK Dementia Research Institute Care Research and Technology Centre at Imperial College London (ICL) as Health and Social Care Lead, moving from NHS clinical services into the field of care research. In this role, Sarah contributes across all core programmes of the centre working alongside the research team in the development of technologies that deliver meaningful improvements for people living with dementia/neurological conditions. She works closely with clinicians and commissioners across the health and social care sector, building integrated systems the infrastructure needed to translate research into scalable, sustainable benefits in the ‘real world’.
Sarah has become a strong proponent for human centred design and acts a clinical advisor to Helix Centre Helixcentre.com. In addition, she provides strategic support / leadership to the Oxford Centre for Enablement and sits on the on the strategy group of the newly established, ICL Rehabilitation Technologies Network.